RNA-Targeted Therapies and Amyotrophic Lateral Sclerosis
نویسندگان
چکیده
منابع مشابه
RNA-Targeted Therapies and Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal motor disease in adults. Its pathophysiology remains mysterious, but tremendous advances have been made with the discovery of the most frequent mutations of its more common familial form linked to the C9ORF72 gene. Although most cases are still considered sporadic, these genetic mutations have revealed the role of RNA production, processing and tra...
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Amyotrophic lateral sclerosis (ALS) research is undergoing an era of unprecedented discoveries with the identification of new genes as major genetic causes of this disease. These discoveries reinforce the genetic, clinical and pathological overlap between ALS and frontotemporal lobar degeneration (FTLD). Common causes of these diseases include mutations in the RNA/DNA-binding proteins, TDP-43 a...
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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that results in progressive degeneration of motor neurons, ultimately leading to paralysis and death. Approximately 10% of ALS cases are familial, with the remaining 90% of cases being sporadic. Genetic studies in familial cases of ALS have been extremely informative in determining the causative mutations behind ALS,...
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Amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease is the most common motor neuron disease in human adults, described as early as 1869 by a French neurobiologist and physician, Jean-Martin Charcot. Although advances in genetics have accelerated the pace of ALS research in the past decade, there is currently only one FDA-approved compound (Riluzole) to treat the disease, a compound that...
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Respiratory complications are a common cause of morbidity and mortality in amyotrophic lateral sclerosis (ALS). Treatment of respiratory insufficiency with noninvasive ventilation (NIV) improves ALS patients' quality of life and survival. Evidence-based practice guidelines for the management of ALS patients recommend treatment of respiratory insufficiency with NIV as well as consideration of in...
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2018
ISSN: 2227-9059
DOI: 10.3390/biomedicines6010009